How should I take Rocaltrol? – What is Chronic Kidney Disease (CKD)?    – Facts about Chronic Kidney Disease    – What are the symptoms of Chronic Kidney Disease?    – What are the risk factors for Chronic Kidney Disease ?    – What causes Chronic Kidney Disease?    – How is vitamin D involved in Chronic Kidney Disease? – How does Rocaltrol work in Patients with Chronic Kidney Disease?    – How should I take Rocaltrol?    – How will my physician know whether my treatment with Rocaltrol is working? •  Rocaltrol is available both as capsules and as an oral solution -  Rocaltrol capsules are available in two different doses: ◊  0.25 micrograms ◊  0.5 micrograms -  The oral Rocaltrol solution contains 1 microgram per ml in a 15 ml. bottle -  You can take either the Rocaltrol capsules or the oral solution -  Take Rocaltrol once a day in the exact manner your physician prescribes -  In order for Rocaltrol to be effective there are several things you need to be aware of: ◊  You need to be receiving an adequate daily intake of calcium, at least 600 milligrams per day. [The US R.D.A. (required daily amount) in adults is 800 milligrams to 1200 milligrams.] The amount of supplemental calcium that you take should be discussed with your doctor. ◊  Be sure to discuss beforehand any current or planned vitamin or nutritional supplement regimens with your physician in order to avoid excess doses of vitamin D while on Rocaltrol therapy. ◊  If you are a dialysis patient on Rocaltrol therapy, your physician may discuss with you the need for a low-phosphate diet and a non-aluminum phosphate-binding compound. ◊  Also, if you are a dialysis patient on Rocaltrol therapy, avoid consuming OTC preparations containing magnesium such as antacids, because use of these could lead to an unhealthy build up of magnesium in your system. References: 1. Rocaltrol [package insert]. Parsippany, NJ: Validus Pharmaceuticals; 2009. © February 2019 Validus Pharmaceuticals LLC. All rights reserved. ROC-021-09

Full Prescribing Information for Rocaltrol Important Safety Information for Rocaltrol® (calcitriol) Capsules and Oral solution Rocaltrol should not be taken if there are symptoms of abnormally elevated vitamin D or calcium levels or if you are allergic to any product ingredient. Taking too much vitamin D can cause high calcium levels, which could trigger serious health problems and may require immediate medical attention. Dosage adjustments of Rocaltrol may be required if other medications are initiated or discontinued; do not stop taking other medications without your physician's knowledge. Potential side effects of Rocaltrol are, in general, similar to effects of taking too much vitamin D. Report early symptoms of elevated vitamin D or calcium including weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle or bone pain, metallic taste, and anorexia, abdominal pain or stomach ache, to your doctor.