Medical Professional Home Page About Rocaltrol About Chronic Kidney Disease hypoparathyroidism Important Safety Information
 
What causes Chronic Kidney Disease?
The two main causes of chronic kidney disease in the United States are diabetes and high blood pressure, which, taken together, are responsible for up to two-thirds of cases. Diabetes happens when your blood sugar is too high, causing damage to many organs in your body, including the kidneys and heart, as well as blood vessels, nerves, and eyes. High blood pressure, or hypertension, occurs when the pressure of your blood against the walls of your blood vessels increases. If uncontrolled, or poorly controlled, high blood pressure can be a leading cause of heart attacks, strokes, and chronic kidney disease. Also, chronic kidney disease can cause high blood pressure.

Other conditions that affect the kidneys are:
glomerulonephritis, a group of diseases that cause inflammation and damage to the kidney's filtering units. These disorders are the third most common type of kidney disease.
Inherited diseases, such as polycystic kidney disease, which causes large cysts to form in the kidneys which affect the ability to clear waste products.
Malformations that occur as a baby develops in its mother's womb. For example, a narrowing may occur that prevents normal outflow of urine and causes urine flow to back up in the kidney. This causes infections and may damage the kidneys.
Lupus and other diseases that affect the body's immune system.
Obstructions caused by problems like kidney stones, tumors, or an enlarged prostate gland in men.
Repeated urinary infections
References:
1. National Kidney Foundation: Chronic Kidney Disease (CKD), National Kidney Foundation Web site. Available at: http://www.kidney.org/kidneydisease/ckd/index.cfm.
 
Full Prescribing Information for Rocaltrol

Important Safety Information for Rocaltrol® (calcitriol) Capsules and Oral solution
Rocaltrol should not be taken if there are symptoms of abnormally elevated vitamin D or calcium levels or if you are allergic to any product ingredient. Taking too much vitamin D can cause high calcium levels, which could trigger serious health problems and may require immediate medical attention. Dosage adjustments of Rocaltrol may be required if other medications are initiated or discontinued; do not stop taking other medications without your physician's knowledge. Potential side effects of Rocaltrol are, in general, similar to effects of taking too much vitamin D. Report early symptoms of elevated vitamin D or calcium including weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle or bone pain, metallic taste, and anorexia, abdominal pain or stomach ache, to your doctor.